Persistent Critical Illness in Newborns

The problem of persistent critical illness (PCI) in newborns is poorly understood. epidemiology this pathological condition has not been precisely established, however, it known that PCI considered a predictor an unfavorable outcome any pathology and proceeds more severely then adults children. Long-term outcomes surviving are associated with subsequent asthenia, cognitive impairment, chronic fatigue syndrome, high incidence disability, complex physiological abnormalities, organ dysfunction from which they rarely recover.Nutritional, respiratory hemodynamic supports key components neonatal therapy. physiology newborn different adult patient; therefore, inotropic therapy category patients requires special approaches. In the past few years, addition to dopamine, dobutamine adrenaline, have prescribed milrinone, norepinephrine, vasopressin, levosimendan as support. clinical potential these drugs neonates still under evaluation but there some evidence for their benefits use PCI.